MicrowaveAblation: Emerging Technology in Cancer Management - AReview

Nwoye EO(1), Ibitoye AZ(2), Aweda MA(3), Oremosu AA(4), Anunobi CC(5), Akanmu ON(6), Adeneye SO(7),


(1) Department of Biomedical Engineering CoUege of Medicine, University of Lagos, Idi-Araba Campus, Lagos
(2) Department of Radiation Biology and Radiotherapy CoUege of Medicine, University of Lagos, Idi-Araba Campus, Lagos
(3) Department of Radiation Biology and Radiotherapy CoUege of Medicine, University of Lagos, Idi-Araba Campus, Lagos
(4) Department of Anatomy, Faculty of Basic Sciences, CoUege of Medicine, University of Lagos, Idi-Araba Campus, Lagos
(5) Department of Morbid Anatomy, Faculty of Basic Sciences College of Medicine, University of Lagos, Idi-Araba Campus, Lagos
(6) Department of Anesthesia, Faculty of Clinical Sciences, CoUege of Medicine, University of Lagos, Idi-Araba Campus, Lagos
(7) Department of Radiation Biology and Radiotherapy CoUege of Medicine, University of Lagos, Idi-Araba Campus, Lagos
Corresponding Author

Abstract


Hyperthermia therapy also called thermal therapy is a type of cancer treatment in which body tissue is exposed to high temperatures. Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. The electromagnetic microwave causes water molecules to vibrate and rotate; resulting in tissue heating and subsequently cell death via thermal induced protein denaturation. Microwave ablation is emerging as an attractive modality for thermal therapy oflarge soft tissue in short periods of time making it suitable in the treatment of liver disease, lung malignancies, renal and adrenal tumours, and bone metastases. Microwave ablation technique in comparison with other thermal therapy techniques demonstrates higher temperature profiles, faster ablation times and larger tumour ablation volumes with minimal effect of perfusion. This review describes physics of microwave ablation, microwave therapy applications in cancer management and prospects and challenges of microwave therapy in cancer management.

Keywords


Microwave, Hyperthermia, Antenna, Ablation, Cancer.

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