The Effects of Intra sound Therapy on the Healing of Tendon Exposed to Alcohol
), Dosumu OO(2), Samuel TA(3), Anunobi CC(4), Duru FI(5), Akinfeleye A(6), Okafor UA(7),
(1) Department of Physiotherapy, College of Medicine, University of Lagos, Lagos, Nigeria
(2) Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria
(3) Department of Biochemistry, College of Medicine, University of Lagos, Lagos, Nigeria
(4) Department of Anatomic and Molecular Pathology, College of Medicine, University of Lagos, Lagos, Nigeria
(5) Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria
(6) Department of Physiotherapy, Lagos University Teaching Hospital, Lagos, Nigeria.
(7) Department of Physiotherapy, College of Medicine, University of Lagos, Lagos, Nigeria
Corresponding Author
Abstract
Background: Functional abnormalities in wound structure has been identified as a potential complication if a patient consumes alcohol prior to injury and studies suggest that even a single incidence of acute ethanol exposure can have adverse effects on the issue response to trauma. Ethanol ingestion has been shown to result in delayed and abnormal tendon healing 3 weeks after injury.
Objective: This study investigated the effects of low intensity intrasound therapy (LlTR) given twice daily on the morphology and antioxidant parameters in the healing tendon following an acute injury in rats exposed to prior ethanol consumption.
Methods: Fifteen male rats, randomized into three groups, all had induced crush injury to the left Achilles tendon. Groups 2 and .., had prior oral administration of30% ethanol for six days while Group I (control) had no alcohol and no follow-up intervention. Group 2 received no treatment while Group 3 had LlTR twice daily.LlTR was commenced immediately post-injury and was given twice daily over the first 6 days. The animals were sacrificed on day 20 post-injury and the tendons were excised, and processed for histology, antioxidant and malondialdehyde (MDA) assay.
Results: The tendons in Group 2 showed disordered and haphazard collagen formation with neutrophilic infiltrates and high tenoblast population at 20 days post-injury while the LITR treated tendon demonstrated dense, organized, parallel collagen deposits with fewer tenoblasts. LlTR also significantly improved the antioxidant parameters and lowered the MDA when compared with the tendon of rats that were fed alcohol but received no treatment (p<0.05).
Conclusion: LIRT reversed the deleterious effect of ethanol on the healing tendon and resulted in near-normal morphology ofthe healing tendon 20 days post-injury
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