Impacts of High Blood Pressure and Ageing on Reproductive Hormones among Nigerian Pre-menopausal Female
), Odia O(2), Ogidi NO(3), Ossai BO(4), Adefolaju FO(5),
(1) Department of Medical Laboratory Science, College of Medicine, University of Lagos, Lagos, Nigeria
(2) Department of Medical Laboratory Science, College of Medicine, University of Lagos, Lagos, Nigeria
(3) Department of Medical Laboratory Science, College of Medicine, University of Lagos, Lagos, Nigeria
(4) Department of Medical Laboratory Science, College of Medicine, University of Lagos, Lagos, Nigeria
(5) Department of Haematology and Blood Transfusion Science, College of Medicine, University of Lagos, Lagos, Nigeria
Corresponding Author
Abstract
Background: Ageing increases the risk of high blood pressure in humans and these two are thought to have impacts on reproductive hormones synthesis.
Objective: This study investigated the possible impacts of hypertension and age on the pre-menopausal female serum reproductive hormone levels.
Materials and Methods: A cross-sectional study was conducted beginning with administration of questionnaire. A total number of 150 pre-menopausal female volunteers (eighty hypertensive and seventy normotensives respectively) between ages 18-45 years were selected to participate in this study. Blood pressure and anthropometric measurement were carried out on all the volunteers and blood sample was collected from each participant at the follicular phase of their menstrual cycle. Samples were assayed for follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone, estradiol (E2) and prolactin using enzyme-linked immunosorbent assay (ELISA).
Results: There was an increase in blood pressure, age, waist circumference (p=0.000), weight and BMI (p=0.020) oftest group. fSH andLHwere significantlyhigher(p=0.000), while prolactin andE2weresignificantly lower(p=0.0 10 andp=O.OOO respectively) among the test group. An evaluation of the degree of association among the parameters studied showed a positive association between age and FSH (p=0.000), LH and FSH (p=0.000), and a negativecorrelation between age and progesterone, age and E2, age and prolactin (p=0.000), LH and progesterone, LH and E2, FSH and E2respectively.
Conclusion: Based on findings from this study, it can be opined that ageing within pre-menopausal women and high blood pressure may impact negatively on the homeostasis of the studied hormones
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