Anti-diabetic Activity of Sanseviera liberica Gerome and Labroy (Agavaceae) Root Extract and Fractions on Alloxan-induced Diabetic Rats

Amao OS(1), Sofidiya MO(2), Olusanya AW(3), Ishola IO(4), Adeyemi OO(5),


(1) Department of Pharmacology, Therapeutics, & Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
(2) Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria.
(3) Department of Pharmacology, Therapeutics, & Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
(4) Department of Pharmacology, Therapeutics, & Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
(5) Department of Pharmacology, Therapeutics, & Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
Corresponding Author

Abstract


Background: The root decoction of Sanseviera liberica Gerome and Labroy (Agavaceae) is used in traditional African medicine
for the treatment of diabetes mellitus, convulsion, earache, and wounds.

Objective: This study sought to investigate the effect of Sanseviera liberica methanol root extract (SL) and its fractions - hexane
(HF), chloroform (CF), ethylacetate (EF) and butanol (BF) on alloxan-induced hyperglycaemia in rats.

Methods: SL (100, 200 or 400 mg/kg, p.o.), and fractions (100 mg/kg, p.o.) or insulin (0.4 IU/kg, positive control) were respectively administered to rats which thereafter were subjected to glucose tolerance (2 g/kg, i.p.) or alloxan-induced hyperglycaemia (150 mg/kg, i.p.) tests for 21 consecutive days. Blood glucose level, glycosylated haemoglobin, liver glycogen, renal and liver functions were assayed.

Results: SL, CF and EF, as well as glibenclamide produced time course and significant reduction in blood glucose level in glucose
tolerance test. Interestingly, alloxan administration increased blood glucose level, glycosylated haemoglobin, alkaline phosphatase (ALP), alanine aspartate transaminase (AST), and albumin which were attenuated by SL, CF, and EF administration. The preliminary phytochemical analysis revealed the presence of flavonoids, phenols, tannins, saponins, cardiac glycosides, terpenoids, anthraquinones and alkaloids.

Conclusion: Findings from this study established the antidiabetic activity of methanolic root extract of S. liberica and its
fractions in rats. Thus, it could be a potential phytomedicine in the management of diabetes.


Keywords


Diabetes, Sanseviera liberica, glycosylated haemoglobin, hypoglycaemia

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